《十一种孤独》以冷峻的笔触描写了美国二战后五六十年代普通纽约人的生活，写了十一种孤独的人生，主人公都是缺乏安全感、生活不太如意的人：曼哈顿办公楼里被炒的白领、有着杰出想象力的出租车司机、屡屡遭挫、一心想成为作家的年轻人、即将结婚十分迷茫的男女、古怪的老教师、新转学的小学生、肺结核病人、老病号的妻子、爵士钢琴手、郁郁不得志的军官、退役军人等。耶茨笔下都是普通人的普通生活，描写的是普通人的孤独、失落与绝望，他自己曾说：“如果我的作品有什么主题的话，我想只有简单一个：人都是孤独的，没有人逃脱得了，这就是他们的悲剧所在。”

The famous opening line of the novel warns of the bleak narrative to follow, "Neither of the Grimes sisters would have a happy life, and looking back it always seemed that the trouble began with their parents’ divorce." Emily and Sarah Grimes are sisters who share little in terms of character but much in terms of disappointment with their lives. Emily, the more intellectual and cosmopolitan of the two, seeks love in numerous disappointing affairs and short-term relationships while Sarah, the prettier and more conventional sister, marries young and bears children to an uncouth and abusive husband. Their troubled, rootless mother, Pookie, like many Yatesian matriarchs, is likely modeled on his own mother, who was nicknamed "Dookie". The novel, beginning in the 1930s when the sisters are children and ending in the 1970s with Sarah's death, primarily revolves around Emily as the book's central character, though the book employs Yates' characteristic and seamless shifts of consciousness throughout.

In the hopeful 1950s, Frank and April Wheeler appear to be a model couple: bright, beautiful, talented, with two young children and a starter home in the suburbs. Perhaps they married too young and started a family too early. Maybe Frank's job is dull. And April never saw herself as a housewife. Yet they have always lived on the assumption that greatness is only just around the corner. But now that certainty is about to crumble.
With heartbreaking compassion and remorseless clarity, Richard Yates shows how Frank and April mortgage their spiritual birthright, betraying not only each other, but their best selves.