Michael Pollan, whose curiosity about our eating habits led to thoughtful, culturally transformative writing in The Omnivore’s Dilemma and, most recently, Food Rules, here explores the potential psilocybin and other psychedelics hold for transformation of the spiritual and emotional kind. As he tells it in How to Change Your Mind, a fascinating, sometimes moving look at the history and uses of psychoactive compounds, Pollan avoided such drugs in his youth, but later in life became intrigued by the opportunity “to become more ‘open’—especially at this age, when the grooves of mental habit have been etched so deep as to seem inescapable.” And then there was the chance of experiencing a spiritual epiphany—“touching the face of God,” as one ecstatic user put it. Pollan’s natural skepticism and wry humor is a good match for the detailed accounts he includes of mind-blowing, trip-induced revelations. Ultimately, whether such experiences lead to genuine insight into, say, the origins of the universe or what we can expect after death seems less interesting to Pollan than the hope psychedelics offer people suffering from depression, addiction, and acute illness. Can magic mushrooms be used more broadly for “the betterment of well people”? Readers who begin reading Pollan’s book feeling doubtful about the responsible use of psychedelics may find their own minds changed by his engaging, enlightened, and persuasive combination of personal and journalistic research. “I felt as if I were standing on the edge of a wide-open frontier, squinting to make out something wondrous,” he writes, and with him as our guide, so do we. —Sarah Harrison Smith, Amazon Book Review