《生物化学》第三版被列为“九五”国家级重点教材和“面向21世纪课程教材”。作者在第二版的基础上，根据国内外生物化学领域的最新进展和参考资料，重新编写完成。这本教材一方面力求与国际名著接轨，反映最新科研成果及现阶段热点问题；另一方面结合中国生物化学高等教育的实际情况，深入浅出，循序渐进，章节上仍采取先“静态”后“动态”的安排。

全书共40章，下册为第19-40章，内容包括代谢总论、生物氧化、糖代谢、脂质代谢、蛋白质分解及氨基酸代谢、核酸的降解与核苷酸代谢、核酸的生物合成、蛋白质的生物合成、物质跨膜运输、生物固氮和光合作用等。每章都附有提要和习题，书后附有生物化学常用名词英汉对照、名词缩写、索引等，以便读者学习。章节仍按“先静态、后动态”组织编排，符合国内的教学习惯，便于教师教学使用和学生自学。

Authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles of biochemistry.
This comprehensive biochemical text covers all aspects of modern biochemistry, together with many new developments since the previous edition of four years ago.
Purpose: The goal is to provide students with a thorough biochemistry text. Given the overall importance of modern biochemistry (broadly writ), this is a worthwhile objective. In general, the goals are met.
The target audience includes senior undergraduate, graduate, and medical students. The authors are both knowledgeable and experienced.
There are several comprehensive biochemistry texts available. The fourth edition of Lehninger draws on a successful history initiated with the first edition which was a landmark text in its time. The 28 chapters follow an expected and logical progression from discussion of the fundamental molecules involved in cellular events through metabolism to the latest aspects of molecular biology. Illustrations are well done and frequent. Each chapter is accompanied by a short but useful bibliography and a set of problems. Problem answers are at the end, together with a detailed glossary and a thorough index. In an attempt to capture as broad a student audience as possible, discussions of both photosynthesis and metabolic diseases are offered. Thus, the material can be used in undergraduate/graduate courses as well as in medical school. As with other representatives of this text style, the typical student is likely to have some difficulty assigning relative importance to a given item considering the overall depth of coverage of topics. Nevertheless, careful reading with some guidance will be rewarding for most scholars and the book will serve as companion text for the usual biochemistry course. The bibliography is not as complete as some, but will provide pointers to additional material. A useful, albeit formidable (for the student) contribution.
This is yet another mega-text, seeking to satisfy all audiences. Not easy for the average student to read, but all of the material is there. Competitors include Voet and Voet, Biochemistry, 3rd edition (John Wiley & Sons, 2004); Devlin, Textbook of Biochemistry with Clinical Correlations, 6th edition (John Wiley & Sons, 2006) (medical focus); and Metzler, The Chemical Reactions of Living Cells, 2nd edition (Elsevier, 2003) (somewhat more comprehensive with an extraordinary bibliography). Is the new edition needed?? Probably, but most students will still be able to use the earlier version. Conversely, other publishers put out new editions, so this one has to.