无须测谎仪，无须确凿证据，甚至无须声音，多数情况下只凭细微的表情变化便可判断的一个人说谎与否，这便是卡尔•莱特曼博士（Tim Roth 蒂姆•罗素 饰）的高超本领。
莱特曼博士供职于一家私人机构，该机构专事微表情的研究，对谎言的判定具有绝对的权威性。当FBI、警察或者民间机构遇到悬而未决的问题之时，便是莱特曼博士及其团队大展身手的好时候。他们凭借丰富的经验和谨慎的作风戳穿一个又一个谎言，将事实真相还原。在他们面前，任何说谎者都无处遁形。
本片根据真人真事改编。

NUMB3RS is a drama about FBI agent Don Eppes (Rob Morrow), who recruits his mathematical-genius brother, Charlie (David Krumholtz) to help the Bureau solve a wide range of challenging crimes in Los Angeles. The two brothers take on the most confounding criminal cases from a very distinctive perspective.

Inspired by actual cases, the series depicts how the confluence of police work and mathematics provides unexpected revelations and answers to the most perplexing criminal questions.

A dedicated FBI agent, Don couldn't be more different from his younger brother, Charlie, a brilliant mathematician who, since he was little, has yearned to impress his big brother. As a seasoned investigator, Don deals in hard facts and evidence, whereas Charlie, a math professor at a California university, functions in a world of mathematical probability and equations.

Now, despite their disparate approaches to life, Don and Charlie are able to combine their areas of expertise and solve some killer cases.