分子生物学
Molecular Biology of the Cell 豆瓣
作者: Bruce Alberts / Alexander Johnson 出版社: Garland Science 2014
Molecular Biology of the Cell is a cellular and molecular biology textbook published by Garland Science and currently authored by Bruce Alberts, Alexander D. Johnson, Julian Lewis (deceased), David Morgan, Martin Raff, Keith Roberts and Peter Walter. The book was first published in 1983 and is now in its sixth edition. The molecular biologist James Watson contributed to the first three editions.
Molecular Biology of the Cell is widely used in introductory courses at the university level, being considered as a reference in many libraries and laboratories around the world. It describes the current understanding of cell biology and includes basic biochemistry, experimental methods for investigating cells, the properties common to most eukaryotic cells, the expression and transmission of genetic information, the internal organization of cells, and the behaviour of cells in multicellular organisms. Molecular Biology of the Cell has been described as “the most influential cell biology textbook of its time”.The sixth edition is dedicated to the memory of co-author Julian Lewis who died in early 2014.
分子克隆实验指南 豆瓣
Molecular Cloning: A Laboratory Manual (Fourth Edition)
作者: MICHAEL R.GREEN / JOSEPH SAMBROOK 出版社: 科学出版社 2013 - 1
Molecular Cloning has served as the foundation of technical
expertise in labs worldwide for 30 years. No other manual has been
so popular, or so influential. Molecular Cloning, Fourth Edition,
by the celebrated founding author Joe Sambrook and new co-author,
the distinguished HHMI investigator Michael Green, preserves the
highly praised detail and clarity of previous editions and includes
specific chapters and protocols commissioned for the book from
expert practitioners at Yale, U Mass, Rockefeller University, Texas
Tech, Cold Spring Harbor Laboratory, Washington University, and
other leading institutions. The theoretical and historical
underpinnings of techniques are prominent features of the
presentation throughout, information that does much to help
trouble-shoot experimental problems.
For the fourth edition of this classic work, the content has
been entirely recast to include nucleic-acid based methods selected
as the most widely used and valuable in molecular and cellular
biology laboratories.
Core chapters from the third edition have been revised to
feature current strategies and approaches to the preparation and
cloning of nucleic acids, gene transfer, and expression analysis.
They are augmented by 12 new chapters which show how DNA, RNA, and
proteins should be prepared, evaluated, and manipulated, and how
data generation and analysis can be handled.
The new content includes methods for studying interactions
between cellular components, such as microarrays, next-generation
sequencing technologies, RNA interference, and epigenetic analysis
using DNA methylation techniques and chromatin immunoprecipitation.
To make sense of the wealth of data produced by these techniques, a
bioinformatics chapter describes the use of analytical tools for
comparing sequences of genes and proteins and identifying common
expression patterns among sets of genes.
Building on thirty years of trust, reliability, and authority,
the fourth edition of Molecular Cloning is the new gold
standard—the one indispensable molecular biology laboratory manual
and reference source.
Molecular Biology of the Cell, Fourth Edition 豆瓣
作者: Bruce Alberts / Alexander Johnson 出版社: Garland 2002 - 3
Molecular Biology of the Cell is the classic in-depth text reference in cell biology. By extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and create a coherent framework through which non-expert readers may approach the subject. Written in clear and concise language, and beautifully illustrated, the book is enjoyable to read, and it provides a clear sense of the excitement of modern biology. Molecular Biology of the Cell sets forth the current understanding of cell biology (completely updated as of Autumn 2001), and it explores the intriguing implications and possibilities of the great deal that remains unknown.
The hallmark features of previous editions continue in the Fourth Edition. The book is designed with a clean and open, single-column layout. The art program maintains a completely consistent format and style, and includes over 1,600 photographs, electron micrographs, and original drawings by the authors. Clear and concise concept headings introduce each section. Every chapter contains extensive references. Most important, every chapter has been subjected to a rigorous, collaborative revision process where, in addition to incorporating comments from expert reviewers, each co-author reads and reviews the other authors' prose. The result is a truly integrated work with a single authorial voice.</P>
Molecular Biology of the Gene 豆瓣
作者: James D. Watson / Tania A. Baker 出版社: Benjamin Cummings 2004 - 1
Every student package automatically includes a CD-ROM and access to a website containing tutorials, molecular models, and more.
The long-awaited Fifth Edition of James D. Watson's classic text, Molecular Biology of the Gene, has been thoroughly revised and is published to coincide with the 50th anniversary of Watson and Crick's paper on the structure of the DNA double- helix.
Despite being completely updated, the new edition retains the distinctive character of earlier editions that made it the most widely used book in molecular biology. Twenty-one concise chapters, co-authored by five highly respected molecular biologists, provide current, authoritative coverage of a fast-changing discipline. The completely new art is printed in full colour for the first time.
Divided into four parts, the first (Genetics and Chemistry) begins with an overview of molecular biology, placing the discipline in historical context and introducing the basic chemical concepts that underpin our description of molecular biology today. The second part (Central Dogma) forms the heart of the book, describing in detail the basic mechanisms of molecular biology. The third part of the book (Regulation) deals with how gene expression is regulated - from the examination of basic mechanisms that regulate gene expression in bacterial and eukaryotic systems, to a description of how regulation of gene expression lies at the heart of the process of development. Recent findings from sequencing whole genomes of several animals have revealed that they all share essentially the same genes. The last chapter in the regulation section looks at how changes in gene regulation can account for how different animals can be made from the same genes. The final part of the book (Methods) deals with the techniques and methods used in molecular biology.
[Contents]
I. CHEMISTRY AND GENETICS.
1. The Mendelian View of the World.
2. Nucleic Acids Convey Genetic Information.
3. The Importance of Weak Chemical Interactions.
4. The Importance of High Energy Bonds.
5. Weak and Strong Bonds Determine Macromolecular Interactions.
II. CENTRAL DOGMA.
6. The Structures of DNA and RNA.
7. Chromatin and the Nucleosome.
8. The Replication of DNA.
9. The Mutability and Repair of DNA.
10. Homologous Recombination of DNA.
11. Site Specific Recombination and Transposition of DNA.
12. Mechanisms of Transcription.
13. The Processing of RNA.
14. Translation.
15. The Genetic Code.
III. REGULATION.
16. Gene Regulation in Prokaryotes.
17. Gene Regulation in Eukaryotes.
18. Gene Regulation in Development.
19. Comparative Genomics and the Evolution of Animal Diversity.
IV. METHODS.
20. Techniques of Molecular Biology.
21. Model Systems: Cells and Viruses.
[Features]
Early chapters on chemical and molecular interactions give a richer context to the material that follows and stress the importance of weak chemical interactions in biology.
The text has balanced coverage of prokaryotic and eukaryotic systems.
Important experiments and techniques relevant to chapter concepts are revealed in boxes in every chapter. These include recent techniques from the fields of genomics and bioinformatics.
Quantitative and critical thinking end-of-chapter questions allow students to apply their knowledge of the chapters key concepts.
An all new art programme features more than 750 line drawings in full colour. In addition, the art in the text has been integrated into animations on the accompanying CD-ROM and website.
The lively, incisive writing style that characterized earlier editions is once again a hallmark in the new edition.
Integrated media helps students better understand complex structures and molecular interactions. The CD-ROM and website offer animated tutorials, critical thinking exercises, and 3-D interactive molecular models in Chime.
The Eighth Day of Creation 豆瓣 Goodreads
The Eighth Day of Creation: Makers of the Revolution in Biology
作者: Horace Freeland Judson 出版社: Cold Spring Harbor Laboratory Press,U.S. 1996 - 1
In this classic, originally published 25 years ago and now reprinted with a new Afterword by the author on how he came to write the book, Judson tells the story of the birth and early development of molecular biology, in the US, the UK and France. In particular, the fascinating account of the remarkable golden period from the revelation of the double helix structure of DNA through to cracking the genetic code and solving the basic problems of how genes are regulated, is told largely in the words of the main players in the unfolding drama, all of whom were interviewed extensively by Judson in preparing this acclaimed volume. As well as the new Afterword that appears here for the first time, the current edition contains the material added by the author to the earlier "Expanded Edition" (CSHL Press 1996) on some of the principal figures involved, particularly Rosalind Franklin, together with the Afterword added at that time which sketches the further development of molecular biology into the era of recombinant DNA.
神经元突触传递的细胞和分子生物学 豆瓣
2008
《神经元突触传递的细胞和分子生物学》采用了众多彩色图表,不但突出了基本概念的阐述,也对基本研究方法和发展趋势作了介绍,把经典内容和前沿知识进行了有机结合。神经递质释放与跨膜信息的传递及整合是神经细胞最基本的功能特征,对突触传递机制的研究是人类认识复杂神经系统功能的前提,是科学领域近百年来重点探索的核心问题之一,也是神经科学中极其重要的前沿领域。《神经元突触传递的细胞和分子生物学》主编盛祖杭教授目前担任美国国立健康研究院神经突触功能研究室主任、首席研究员,教育部“长江学者奖励计划”讲座教授。在编写《神经元突触传递的细胞和分子生物学》时他大量引用了在美国15年从事神经科学研究、教学的成果和创见,以神经系统的基本功能——突触传递为核心,较系统地、深入浅出地介绍了突触的结构、神经元的细胞骨架系统和物质的合成转运、突触传递及其调节机制等一系列有关神经生物学的核心问题,从细胞和分子水平详细阐述了神经递质释放与跨膜信息传递及整合的过程以及机制,从而揭示大脑复杂的功能活动。
《神经元突触传递的细胞和分子生物学》可作为神经生物学专业教师和有关科研人员的参考读物,也可作为综合性大学生物系和医学院校高年级本科生、研究生阅读参考。
Molecular Biology of the Cell 豆瓣
作者: Bruce Alberts / Alexander Johnson 出版社: Garland Science 2008 - 1
For nearly a quarter century, "Molecular Biology of the Cell" has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter). The hallmark features of "Molecular Biology of the Cell" have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries. Additionally, in response to extensive feedback from readers, the Fifth Edition now includes several new features. It is now more portable. Chapters 1-20 are printed and Chapters 21-25, covering multicellular systems, are provided as PDF files on the free Media DVD-ROM which accompanies the book. And for the first time, "Molecular Biology of the Cell" now contains end-of-chapter questions. These problems, written by John Wilson and Tim Hunt, emphasize a quantitative approach and the art of reasoning from experiments, and they will help students review and extend their knowledge derived from reading the textbook. The Media DVD-ROM, which is packaged with every copy of the book, contains PowerPoint[registered] presentations with all of the figures, tables and micrographs from the text (available as JPEGs too). Also included is the Media Player, which plays over 125 movies - animations, videos, and molecular models - all with voice-over narration. A new reader-friendly feature is the integration of media codes throughout the text that link directly to relevant videos and animations. The Media DVD-ROM holds the multicellular systems chapters (21-25) of the text as well. By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and thereby create a coherent framework through which readers may approach and enjoy this subject that is so central to all of biology. There is also a reference edition of "Molecular Biology of the Cell, Fifth Edition" (ISBN 978-0-8153-4111-6) that contains Chapters 1-25 entirely in printed format.
分子生物学 豆瓣
作者: Robert F.Weaver 译者: 郑用琏 出版社: 科学出版社 2010 - 1
《分子生物学:原书第4版》是生命科学相关专业的本科生、研究生及从事该方面科研、教学人员不可多得的一本参考用书。分子生物学是生命科学发展过程中诞生的一门实验性极强的新兴学科。美国著名分子生物学家Robert F.Weaver遵循这一学科发展的特点,于1999年出版了Molecular Biology一书的第一版。全书以原始研究论文为基础,通过对实验的设计、对结果的分析而逐步展开对分子生物学理论的讲述。文字通俗流畅。叙述由浅入深。随着学科的迅速发展,几经修订再版的Molecular Biology第四版共有导论,分子生物学方法,原核生物、真核生物转录.转录后加工,翻译,DNA复制、重组和转座。以及基因组学等8部分24章,书后还附有词汇表。每一章节都以提出科学问题、展开研究过程开始,以提供思考习题、推荐阅读文献结束,理论讲述逻辑严密,实验过程提炼清晰,特色鲜明、内容详尽,图文并茂,易读易记。
创世纪的第八天 豆瓣
The Eighth Day of Creation : Makers of Revolution in Biology
作者: [美] 霍勒斯·贾德森 译者: 李晓丹 出版社: 上海科学技术出版社 2005 - 1
本书共分三篇,内容包括:“DNA功能与结构:阐明脱氧核糖核酸(遗传物质)的结构”、“RNA结构的功能:破解遗传密码,发现信使”、“蛋白质结构和功能:蛋白质分子是怎样工作的”。
双螺旋 豆瓣
作者: [美] J. D. 沃森 译者: 吴家睿 评点 出版社: 科学出版社 2006 - 2
《双螺旋:发现DNA结构的故事》内容简介:20世纪在科学发展史上是一个辉煌的世纪,以物理学和生物学的创新性成果为标志的科学成就,极大地改变了世界的面貌,改变了人类的认知水平、生产方式和生活方式。20世纪也是科学史上的一个英雄世纪,一大批别具一格的科学大师风云际会,相继登场,使科学的舞台展现出前所未有的绚丽风采。20世纪发生了两次世界大战,二战催生的原子弹,使社会公众了解了科学的巨大威力,也促使人类认真地审视科学,了解到科学必须要与人类的良知,与人文精神结合在一起,只有合理地利用,才能造福于人类,才能有利于和平,有利于人类社会的可持续发展。进入20世纪80年代,人类更进一步认识到必须携起手来保护生态,控制环境污染,探索可持续发展的道路。可持续发展理念的形成,是20世纪阶级社会发展观进步的一个重大的事件。
回顾20世纪科学走过的道路,从突飞猛进的科学创造,到科学与人文伦理的深度撞击,形成与人文精神交融并进的局面,最终在人类文明史上留下了不同寻常的篇章。
基因X 豆瓣
作者: Krebs 出版社: 高等教育出版社 2010 - 1
分子生物学与分子遗传学领域正经历着日新月异的变化,每天都会出现新的数据,那些热门的研究进程,过去每隔数年才会出现新的见解和看法,现在只要几周或几个月。在过去几十年里,对广大教学者来说,Lewin的《基因》是一本十分优秀的教材,该书对分子生物学和分子遗传学进行了精彩的论述,内容涵盖了基因的结构、序列、组织和表达。最新版的Lewin《基因X》,拥有一支崭新的作者队伍,21位科学家根据各自的专业研究特长,对书中内容进行了修订和更新,以保证《基因X》是本领域最新颖全面的教材。《基因X》在内容上增加了一些新的章节,结构也进行了一些调整,使得全书各个主题在排列上更加富有逻辑性。另外许多章节也重新命名,和内容更加相符。新版中还包含了一些新的教学特色,便于学生在阅读本书过程中更好地学习;增加了在线学习导航,学生可以使用它对关键内容进行自我测试。
新版特色
 全新的第3章——分子生物学和基因工程方法,详细介绍了分子生物学实验技术的概念和实践。
 新加入的第8章——基因组进化,对于早期版本分散在各章节中的相关材料做了整合、扩展和更新,并介绍了一些新进展。
 第22章——mRNA的稳定性和定位,完全更新并重写,以包含更多的前沿内容。
 第30章——调控RNA和小RNA,特别引入了RNAi通路的相关内容。
 大量崭新的精美插图反映了相关领域的新进展,尤其是基因组结构和功能、表观遗传学,以及原核生物中非编码和小RNA的调控。
英汉分子生物学百科辞典 豆瓣
作者: 约翰·肯德鲁爵士 译者: 《英汉分子生物学百科辞典》翻译委员会 出版社: 上海科学技术出版社 2004 - 1
本书共含有55多条长度不等的条目,以字母先后安排顺序,本书还按相关领域分类,列出本书的第5~7页.本书的目的是为分子生物学本身的核心论题提供一个全面、综合、简明的参考来源,同时本书也包括分子生物学曾为之作出巨大贡献的其他领域的一般背景材料
基因的分子生物学(第七版) 豆瓣
Molecular Biology of the Gene
作者: J.D.沃森 / T.A.贝克 译者: 杨焕明 出版社: 科学出版社 2015 - 3
本书由DNA双螺旋的发现者之一JamesD.Watson及其他几位著名学者在第六版的基础上修订完成。本书除了反映分子生物学领域的最新进展之外,还涉及其他诸多方面的内容。此次再版仍保留了上一版中的许多定义和特点,而且新增了大量习题,并重写了蛋白质结构和生命进化两章,同时对每一章的内容进行了大量更新。