生物
The Immortal Life of Henrietta Lacks 豆瓣 Goodreads
The Immortal Life of Henrietta Lacks
作者: Rebecca Skloot 出版社: Crown Publishing Group 2010 - 2
Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells—taken without her knowledge—became one of the most important tools in medicine. The first “immortal” human cells grown in culture, they are still alive today, though she has been dead for more than sixty years. If you could pile all HeLa cells ever grown onto a scale, they’d weigh more than 50 million metric tons—as much as a hundred Empire State Buildings. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects; helped lead to important advances like in vitro fertilization, cloning, and gene mapping; and have been bought and sold by the billions.
Yet Henrietta Lacks remains virtually unknown, buried in an unmarked grave.
Now Rebecca Skloot takes us on an extraordinary journey, from the “colored” ward of Johns Hopkins Hospital in the 1950s to stark white laboratories with freezers full of HeLa cells; from Henrietta’s small, dying hometown of Clover, Virginia—a land of wooden slave quarters, faith healings, and voodoo—to East Baltimore today, where her children and grandchildren live and struggle with the legacy of her cells.
Henrietta’s family did not learn of her “immortality” until more than twenty years after her death, when scientists investigating HeLa began using her husband and children in research without informed consent. And though the cells had launched a multimillion-dollar industry that sells human biological materials, her family never saw any of the profits. As Rebecca Skloot so brilliantly shows, the story of the Lacks family—past and present—is inextricably connected to the dark history of experimentation on African Americans, the birth of bioethics, and the legal battles over whether we control the stuff we are made of.
Over the decade it took to uncover this story, Rebecca became enmeshed in the lives of the Lacks family—especially Henrietta’s daughter Deborah, who was devastated to learn about her mother’s cells. She was consumed with questions: Had scientists cloned her mother? Did it hurt her when researchers infected her cells with viruses and shot them into space? What happened to her sister, Elsie, who died in a mental institution at the age of fifteen? And if her mother was so important to medicine, why couldn’t her children afford health insurance?
Intimate in feeling, astonishing in scope, and impossible to put down, The Immortal Life of Henrietta Lacks captures the beauty and drama of scientific discovery, as well as its human consequences.
神经信息学——神经系统的理论和模型 豆瓣
作者: 汪云九/国别: 出版社: 高等教育出版社 2006 - 6
《神经信息学(神经系统的理论和模型)》把半个世纪以来有实验依据的神经系统(脑)中的主要理论和模型集中起来,给研究生们提供理论训练。这些理论和模型中有重要基础理论意义的,大都取材于诺贝尔奖获得者的工作(Hodgkin、Huxley、Hartline、Gabor、Bekesy、Eccles、Crick、Edelmen、Sperry……),也包括对信息科学、工程应用有重大影响的假设、理论和算法(Hebb学习律、平行分布式理论框架……)。
《神经信息学(神经系统的理论和模型)》共分三篇:第一篇包括固定结构的神经系统的理论模型,涵盖神经元模型、感受器的数学描述、节律产生和视觉信息加工等;第二篇是关于学习和记忆的理论模型,包括}tebb学习律、平行分布式理论框架、Hopfield模型以及短时程的突触修正规律,清晰讲述了神经系统的理论研究对人工智能、信息科学工程应用的意义;第三篇介绍神经科学和脑科学中当前的几个热点,包括神经编码、功能柱的结构和功能、脑的非线性和意识问题。
《神经信息学(神经系统的理论和模型)》可作为神经科学、认知科学、心理学等专业的研究生教材,也可作为人工视觉、神经假肢、人工智能、信息科学专业研究人员的参考书。
自达尔文以来 豆瓣
作者: [美国] 斯蒂芬·杰·古尔德 译者: 田洺 出版社: 生活·读书·新知三联书店 2003
这本科学家撰写的散文杰作,收集了古尔德在《自然史》杂志上发表的科学随想。作者在哈佛大学教生物学,是科学内行,又有历史家的眼光。他提出了一个问题:达尔文在确立了进化论之后,为什么迟了20年才发表?古尔德说,这是因为他清楚进化论的含义比一般人所意识到的更为离经叛道。
人及动物病原细菌学 豆瓣
作者: 杨正时 出版社: 河北科学技术出版社 2003 - 3
本书由来自全国40多所高等院校、科研单位、细菌学检验部门及医院等的90余位细菌学知名专家、学者共同编著,本书共3篇106章。
上篇(细菌学基础)的17章涵盖了有关细菌方面的主要基础知识,同时记述了一些主要的研究历程与现状;中篇(病原细菌)的64章囊括了人及动物一些主要病原细菌,除分别记述了这些细菌的相应特性外,主要记述了其病原学意义、鉴定方法及研究进展等,另外对一些非病原性但与人、动物健康直接相关的细菌也有描述;下篇(细菌检验技术)的25章系统地介绍了细菌学检验技术与具体内容,包括经典方法及近年研究报道较多并已被学术界所公认的方法;在附录A和附录B中,分别记述了细菌快速检验的研究进展及实用方法。
本书基础理论内容丰富,技术方法可操作性强,融指导研究与实践应用为一体。适合相应高等院校师生、细菌学科研工作者及检验技术人员使用。既可从中了解和掌握有关理论知识和技术方法,又可开阔研究思路,是一部极有价值的工具书。
The Sixth Extinction 豆瓣
作者: Elizabeth Kolbert 出版社: Henry Holt and Co. 2014 - 2
A major book about the future of the world, blending intellectual and natural history and field reporting into a powerful account of the mass extinction unfolding before our eyes
Over the last half a billion years, there have been five mass extinctions, when the diversity of life on earth suddenly and dramatically contracted. Scientists around the world are currently monitoring the sixth extinction, predicted to be the most devastating extinction event since the asteroid impact that wiped out the dinosaurs. This time around, the cataclysm is us. In The Sixth Extinction, two-time winner of the National Magazine Award and New Yorker writer Elizabeth Kolbert draws on the work of scores of researchers in half a dozen disciplines, accompanying many of them into the field: geologists who study deep ocean cores, botanists who follow the tree line as it climbs up the Andes, marine biologists who dive off the Great Barrier Reef. She introduces us to a dozen species, some already gone, others facing extinction, including the Panamian golden frog, staghorn coral, the great auk, and the Sumatran rhino. Through these stories, Kolbert provides a moving account of the disappearances occurring all around us and traces the evolution of extinction as concept, from its first articulation by Georges Cuvier in revolutionary Paris up through the present day. The sixth extinction is likely to be mankind's most lasting legacy; as Kolbert observes, it compels us to rethink the fundamental question of what it means to be human.
美德的起源 豆瓣
The Origins of Virtue: Human Instincts and the Evolution of Cooperation
作者: 麦特·里德雷 译者: 方珩 出版社: 中央编译出版社 2003 - 8
文化与艺术人类学译丛。《洛杉矶时报》评之为全年度最佳图书之一。《纽约时报》评之为杰出读物。
对人类最基本的本能——互助与信任所作的细致研究。如果真如达尔文所说,进化实行的是严格的适者生存原则,那么人类为什么还要相互协作,形成复杂的有机社会?本书对人类信任与美德进行了饶有趣味的研究,并向我们展示了近年来相关的研究成果——个体私欲与互助并非绝不相容。实际上,人类的合作本能或许就是作为人类与生俱来的自私行为的一部分进化发展来的。互助协作能让我们自己和他人都从中受益。《美德的起源》一书对来自遗传学、心理学和人类学的最新研究成果进行了精心编排,重新审视了指导人类行动的诸多假设,比如,我们为什么要赡养父母?为什么要照顾兄弟姐妹?为什么要将生意伙伴的利益也考虑在内?作者向我们展示了计算机程序、微生物学以及经济学理论对研究人类个体间关系所提供的独特研究视角。正如作者本人所说:“社会之所以能够运作,并不是人类有意使然,而是因为它是进化过程中出现的人类秉性。确切地说,它就是人性的一部分。”
"小猎犬"号科学考察记 豆瓣
作者: 〔英〕查尔斯·罗伯特·达尔文 (Charles Robert Darwin) 译者: 李光玉 / 孔雀 出版社: 译言古登堡计划/中国青年出版社 2014 - 8
英国皇家海军“小猎犬”号是一艘“切罗基”级10炮双桅帆船,于1820年5月11日下水。这艘军舰在建成之初并没太大用武之地,后被改装为三桅考察帆船。1831年,年轻的查尔斯·达尔文先生登船参加了它的第二次考察之旅,之后他出版的这部《“小猎犬”号科学考察记》使得这艘船蜚声全球,名垂青史。
“小猎犬”号的成名,只是从侧面说明了这次考察的重要性。对于达尔文先生本人来说,更是意义重大:通过这次旅行,达尔文远离固步自封的“文明”社会,投入到一个真实的新世界;他一边仔细地收集事实,一边对这些事实进行理论讨论——当时真正能做到这一步的人是不多的。所以说,“小猎犬”号之旅使达尔文完成了一次卓越的蜕变,他变成了一个独立思考的、富有冒险精神的科学家,一个敢于接受物种演变“异端思想”的科学伟人。
“  小猎犬”号这次著名旅程的点点滴滴被达尔文先生细致而有条理地记录在了这本《“小猎犬”号科学考察记》里,达尔文先生的诸多著名发现和重要证据被收录进了本书后的《“小猎犬”号科学考察动物志》。就请广大读者随这部意义非凡的科学名著,重温达尔文先生的那次改变人类文明的发现之旅吧!
Principles of Neural Science 豆瓣 Goodreads
作者: Eric R. Kandel / James H. Schwartz 出版社: McGraw-Hill Medical 2000 - 1
This is the most authoritative introduction to the brain, its structure, function, development, and control of behavior available today. It presents both a comprehensive summary of the state of the science and a full discussion of historical issues in the study of the brain. Neuroanatomy, cell and molecular mechanisms, mechanisms, of signaling, and development are thoroughly described in the context of the cognitive approaches to behavior. Thoroughly revised, with a new full-color art program, this text was re-designed to be more user friendly. Also featured is an expanded treatment of the development of the nervous system, the genetic basis of neurological and psychiatric diseases, the cognitive neuroscience of perception, and icon channel mechanisms.
分子生物学 豆瓣
作者: Robert F.Weaver 译者: 郑用琏 出版社: 科学出版社 2010 - 1
《分子生物学:原书第4版》是生命科学相关专业的本科生、研究生及从事该方面科研、教学人员不可多得的一本参考用书。分子生物学是生命科学发展过程中诞生的一门实验性极强的新兴学科。美国著名分子生物学家Robert F.Weaver遵循这一学科发展的特点,于1999年出版了Molecular Biology一书的第一版。全书以原始研究论文为基础,通过对实验的设计、对结果的分析而逐步展开对分子生物学理论的讲述。文字通俗流畅。叙述由浅入深。随着学科的迅速发展,几经修订再版的Molecular Biology第四版共有导论,分子生物学方法,原核生物、真核生物转录.转录后加工,翻译,DNA复制、重组和转座。以及基因组学等8部分24章,书后还附有词汇表。每一章节都以提出科学问题、展开研究过程开始,以提供思考习题、推荐阅读文献结束,理论讲述逻辑严密,实验过程提炼清晰,特色鲜明、内容详尽,图文并茂,易读易记。
生物过程工程 豆瓣
译者: 陈涛 2008 - 4
《生物过程工程:基本概念(原著第2版)》是一本世界上最新、最重要的生物化学及生物过程工程方面的教科书。《生物过程工程:基本概念(原著第2版)》作者舒勒和卡基博士概述了生物化学、微生物和分子生物学的相关基础,介绍了能使生物过程工程师对生物活动进行可靠控制的重要原理。《生物过程工程:基本概念(原著第2版)》反映了生物科学技术领域的巨大进展,包括从基因组测序到利用重组DNA技术生产蛋白质的新技术;介绍了在下述方面具有广泛应用的技术:药物、生物制品和大宗化学品生产;在组织工程及基因治疗等医学方面的应用;解决重要的环境问题。
《生物过程工程:基本概念(原著第2版)》重要内容包括:必需的生物学基础(微生物结构与功能,主要的代谢途径,酶,微生物遗传学,微生物生长动力学,计量学);蛋白质翻译后加工的新视野——生产治疗蛋白的一种基本技术;动物细胞培养过程的深入概括;非糖代谢的新视野;功能基因组学与细胞工程(概念、技术及应用);生物加工过程工程方法在生物医学中的应用;非传统生物系统的应用(包括用重组DNA技术生产蛋白质的宿主一载体系统);扩大范围的混合培养:包括先进的废水处理过程;模型模拟的扩充(包括连续培养和控制论模型);迅速发展的政府调控环境如何约束生物过程设计与改进。
《生物过程工程:基本概念(原著第2版)》无论在广度还是深度上都是一本优秀的教科书,同时还配有大量的例证、例题、习题及进一步阅读的文献,因而更便于教学及参考。书中还以附录的形式详细叙述了传统的生物加工过程。
人类的演化 豆瓣
Human Evolution
8.8 (8 个评分) 作者: [英] 罗宾·顿巴 译者: 余彬 出版社: 上海文艺出版社 2016 - 8
是什么让我们成为人类?
我们怎么发展出了语言、思维和文化?
为什么我们存活下来,而其他的人科物种却灭绝了?
人类演化的故事,比任何其他故事都更让我们着迷。我们的好奇心永不满足,总是不断在问:我们是谁?来自哪里?本书对人类演化历程提出了全新的疑问,也给出了崭新的研究方式和回答。
“这是一个侦查的过程,呈现在我们面前的,是一个由考古学记录组成的犯罪现场。和通常的犯罪现场一样,证据很不完善,让人激动,也让人抓狂,我们的任务就是试图推演出在什么时间,发生了什么,以及背后的动机。”牛津大学人类学家罗宾•邓巴,著名的“邓巴数字”提出者,以社会大脑假说和时间分配模型为侦破工具,犹如最敏锐的侦探,一步一步拼接出人类演化的完整图像。
“一部必读之书!强悍地向我们展示了极富想象力的大脑的运作过程,同时又留下了自由思考的空间。”——《新科学家》New Scientist
Fundamentals of Protein Structure and Function 豆瓣
作者: Buxbaum, Engelbert 出版社: Springer Verlag 2007 - 9
The textbook is clearly written, and is suitable for advanced students, e.g. during their master and PhD course time. It is very suited also for postdocs and young scientists as a textbook if they change fields in their research. The textbook represents a thorough and detailed description of the topics in each of the chapters. As the book selects very important topics of present fundamental research and relevant in medical biochemistry, it can supplement any of the text books in biochemistry and basic medicine already on the market.
Human Blood Plasma Proteins 豆瓣
作者: Schaller, Johann/ Gerber, Simon/ Kaempfer, Urs/ Lejon, Sofia/ Trachsel, Christian 2008 - 6
在线阅读本书
Human Blood Plasma Proteins gives an overview of the proteins found in human blood plasma, with special emphasis on their structure and function and relationship to pathological states and disease. Topics covered include: introduction to blood components and blood plasma proteins blood plasma protein domains, motifs and repeats blood plasma protein families and posttranslational modifications blood coagulation and fibrinolysis the complement system the immune system enzymes inhibitors lipoproteins hormones cytokines and growth factors transport and storage The information of each protein discussed in this book in some detail is summarised at the end of each chapter in a Data Sheet, where one can find the most important data of each protein at one glance. Full cross–referencing to protein databases is given and many of the proteins discussed are accompanied by their 3D structure. Attractively presented in full colour, Human Blood Plasma Proteins is an essential atlas of this proteome for anyone working in biochemistry, protein chemistry and proteomics, structural biology, and medicine.
An Introduction to Systems Biology 豆瓣
作者: Uri Alon 出版社: Chapman and Hall/CRC 2006 - 7
Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The text avoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. "An Introduction to Systems Biology: Design Principles of Biological Circuits" builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.
蛋白质结构与功能 豆瓣
作者: D.惠特福德 译者: 魏群 出版社: 科学出版社 2008 - 3
《蛋白质结构与功能》涉及的知识范围很广,从氨基酸到蛋白质的三维结构及检测方法,酶、膜蛋白、纤维蛋白等的结构功能,酶的催化和动力学,蛋白质的表达、纯化、合成、加工及在细胞中的周转,蛋白质的多样性和蛋白质组学,蛋白质体内外的折叠及蛋白质结构与医学分子生物学的进展等。蛋白质结构功能的研究是从分子水平了解生命现象的基础。
探索基因组学、蛋白质组学和生物信息学 豆瓣
作者: 坎贝尔 出版社: 科学出版社 2007 - 5
本书围绕对基因组学、蛋白质组学和生物信息学的概括描述,向读者介绍了近几年来生物学以及医学生物学研究方法上的发展,以及这些方法在研究思维上的深远影响。作者以通俗易懂的语言将这三个方面组成一个研究、探索问题的互动平台,使读者对生物信息学有一个系统的认识和了解,利于更深入的研究。内容主要包括基因组序列、基因组变异、基因组表达、DNA芯片、蛋白质组学、全基因组学以及基因组学在医学病例中的应用等,同时穿插问题探讨、数学备忘录等使内容更加丰富,并附有图片光盘利于读者参考。
本书可作生物学专业本科生、研究生的生物信息学教材或教学辅导书,亦可供分子生物学、生物化学、细胞生物学以及医学、药学等领域的科研人员参考。
The Greatest Show on Earth 豆瓣
作者: Richard Dawkins 出版社: Free Press 2009
In 2008, a Gallup poll showed that 44 percent of Americans believed God had created man in his present form within the last 10,000 years. In a Pew Forum poll in the same year, 42 percent believed that all life on earth has existed in its present form since the beginning of time. In 1859 Charles Darwin's masterpiece, On the Origin of Species , shook society to its core. Darwin was only too aware of the storm his theory of evolution would provoke. But he surely would have raised an incredulous eyebrow at the controversy still raging a century and a half later. Evolution is accepted as scientific fact by all reputable scientists and indeed theologians, yet millions of people continue to question its veracity. Now the author of the iconic work The God Delusion takes them to task. The Greatest Show on Earth is a stunning counterattack on advocates of "Intelligent Design," explaining the evidence for evolution while exposing the absurdities of the creationist "argument." Dawkins sifts through rich layers of scientific evidence: from living examples of natural selection to clues in the fossil record; from natural clocks that mark the vast epochs wherein evolution ran its course to the intricacies of developing embryos; from plate tectonics to molecular genetics. Combining these elements and many more, he makes the airtight case that "we find ourselves perched on one tiny twig in the midst of a blossoming and flourishing tree of life and it is no accident, but the direct consequence of evolution by non-random selection." The Greatest Show on Earth comes at a critical time: systematic opposition to the fact of evolution is menacing as never before. In American schools, and in schools around the world, insidious attempts are made to undermine the status of science in the classroom. Dawkins wields a devastating argument against this ignorance, but his unjaded passion for the natural world turns what might have been a negative argument into a positive offering to the reader: nothing less than a master's vision of life, in all its splendor.
Essentials of Conservation Biology (Sixth Edition) 豆瓣
作者: Richard B. Primack 出版社: Sinauer Associates, Inc. 2014 - 5
Essentials of Conservation Biology, Sixth Edition combines theory and applied and basic research to explain the connections between conservation biology and ecology, climate change biology, the protection of endangered species, protected area management, environmental economics, and sustainable development. A major theme throughout the book is the active role that scientists, local people, the general public, conservation organizations, and governments can play in protecting biodiversity, even while providing for human needs. Each chapter begins with general ideas and principles, which are illustrated with choice examples from the current literature. The most instructive examples are discussed in boxes highlighting projects, species, and issues of particular significance. Chapters end with summaries, an annotated list of suggested readings, and discussion questions. This new edition comes with extensive summary statements in the text margins, as study aids. Essentials of Conservation Biology, Sixth Edition is beautifully illustrated in full colour, and is written in clear, non-technical language, making it well-suited for undergraduate courses.
怎样观察一棵树 豆瓣
Seeing trees : discover the extraordinary secrets of everyday trees
8.8 (28 个评分) 作者: [美] 南茜·罗斯·胡格(Nancy Ross Hugo) / [美] 罗伯特·卢埃林(Robert Llewellyn) 译者: 阿黛 出版社: 商务印书馆 2016 - 9
人人都知道树长什么样子,对吗?但你真的观察过红花槭上精巧的花朵吗?或是鹅掌楸正在萌发的嫩叶?水青冈的枝条?当你仔细观察一棵树时,一个被形状和细节填充的新世界会向你敞开大门——你将看见你不曾知晓的美,你将用一种全新的方式去欣赏树木。当你能够从一棵树的生长轨迹中感受生命的四季,你会真正领略自然那激励人心的力量与美妙。
《怎样观察一棵树》邀你将细致敏锐的目光投向身边常见的树木,并关注一些罕见却易于观察的树木特征。作者将定期细致观察树木的收获娓娓道来,清晰地列举了改进观察方法的策略,图文并茂地呈现了树木微妙而常被忽略的细节构造。对美国白栎、荷花玉兰、北美乔松、北美鹅掌楸等10种常见树木的深入描摹会让你感受到许多小小的震动,重新发现身边的自然奇迹
Molecular Biology of the Cell 豆瓣
Molecular Biology of the Cell
作者: Bruce Alberts / Alexander Johnson 出版社: Garland Science 2007 - 11
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For nearly a quarter century "Molecular Biology of the Cell" has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter). The hallmark features of "Molecular Biology of the Cell" have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries.Additionally, in response to extensive feedback from readers, the Fifth Edition now includes several new features. It is now more portable. Chapters 1-20 are printed and Chapters 21-25, covering multicellular systems, are provided as pdf files on the free Media DVD-ROM which accompanies the book. And for the first time, "Molecular Biology of the Cell" now contains end-of-chapter questions. These problems, written by John Wilson and Tim Hunt, emphasize a quantitative approach and the art of reasoning from experiments, and - they will help students review and extend their knowledge derived from reading the textbook.The Media DVD-ROM, which is packaged with every copy of the book, contains PowerPoint[registered] presentations with all of the figures, tables and micrographs from the text (available as JPEGs too). Also included is the Media Player, which plays over 125 movies -animations, videos, and molecular models - all with voiceover narration. A new reader-friendly feature is the integration of media codes throughout the text that link directly to relevant videos and animations. The Media DVD-ROM holds the multicellular systems chapters (21-25) of the text as well. By skillfully extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and thereby create a coherent framework through which readers may approach and enjoy this subject that is so central to all of biology. There is also a reference edition of "Molecular Biology of the Cell, Fifth Edition" (ISBN 978-0-8153-4111-6) that contains Chapters 1-25 entirely in printed format.