《奇面馆事件》在日本出版之际，正逢绫辻行人作家生涯25周年。距离意气风发创作“十角馆”的年岁转眼间已经过去了四分之一个世纪，距离简体中文版的初次引进也已经十年了，绫辻老师也好，还是我们这些读者也好，也都跟着时代一起成长、成熟了不少。当“馆系列”进行到第九作，字里行间还是能感受到老师的创作热情，布局依旧出色，推理的逻辑性也仍旧一流。享受这部作品，颇像是与一位旧别的老友重逢，看看他的容颜、听听他的声音，就已经心满意足了。

五行塔，一座位于云南腾冲地区的奇怪建筑，五层塔身由五种不同的材质构造而成，分别对应五行中的金木水火土五种元素。有传言说，五行塔受过诅咒，尤其是塔顶的房间最为不祥，住在其中的人终将遭遇不幸。
富商林志坚成了五行塔最新的牺牲品，他自塔顶的密闭房间坠落，却并没有任何自杀的理由。正当警方束手无策之际，新的命案接踵而至，群龙无首的林家陷入到更大的恐慌之中……帮助警方屡破奇案的数学家陈爝，能找到这栋诡异建筑的秘密所在吗？

一个雨后的周末夜晚，来自费城的年轻律师吉尔．安吉尔驱车前往特伦顿郊区一处人迹罕至的破旧木屋与妹夫见面，却在屋内发现了倒卧在血泊中、身受重伤的妹夫，他临终前说出凶手是个戴着面纱的女人。
侦探作家埃勒里·奎因受托调查凶案，竟然发现死者是个拥有双重身份的重婚者，他一方面是纽约富豪的独生女洁西卡的丈夫，过着奢华的生活；另一个身份是个四处兜售廉价首饰的推销商，与年轻貌美的妻子露西住在一间不起眼的小屋子里。
警方调查结果，发现死者投保了一百万美金的巨额人寿险，而且在遇害前不久才将受益人由洁西卡变更为露西，接着又发现露西的车子在命案当晚撞坏在离现场不远的地方，车上还有一条黑色面纱。一切证据都指向凶手就是露西，露西因此被捕待审，吉尔与艾勒里都认为凶手另有其人。

故事发生在一座孤山上。森林大火正在往山顶侵吞，奎因父子爬行在山上，觉得无助、疑惑，在最终找到临时的避难所后，又遇上了一起离奇的凶杀案：避难所的主人死在书房中，凶手无疑就在避难所中他们这一群身处不平常境地的人之中。

As synthetic biology transforms living matter into a medium for making, what is the role of design and its associated values?
Synthetic biology manipulates the stuff of life. For synthetic biologists, living matter is programmable material. In search of carbon-neutral fuels, sustainable manufacturing techniques, and innovative drugs, these researchers aim to redesign existing organisms and even construct completely novel biological entities. Some synthetic biologists see themselves as designers, inventing new products and applications. But if biology is viewed as a malleable, engineerable, designable medium, what is the role of design and how will its values apply?
Review
Far from an ivory tower text, Synthetic Aesthetics is a true collaboration between scientists, designers and thinkers who cross borders and disciplines to test the limits of biology in the digital world. Can bacteria be programmed to alert you when you're ill? Will we one day devise a synthetic organism that can suck up pollution in the wild? Is it possible to decentralise the petrochemical industry and distribute production and power? How long until machines take on lives of their own? Sooner than most of us imagine, it seems. By joining forces, the authors are able to bring disparate theories into the world, closer to life and into language even the laymen can understand.—Wallpaper—
Synthetic Aesthetics…is a freewheeling book with 20 authors and may irritate conventional scientists—some of the ideas were dreamed up while 'performing a dance based on the myth of the Golem', for example. But it certainly explains the key ideas of the field and leads you to many lateral conversations about what it may become. In the first few chapters, one central concern is what is meant by 'design'. An engineer might think of designing a bridge to a particular specification; a synthetic biologist of designing a microorganism with a new commercial application, pumping out green gasoline for example; but a real designer, a fashion designer, for example, is doing something else. As artist Daisy Ginsberg puts it, design 'is about possibility', the unimagined things that life could be. Synthetic biology, she writes, has been addressing 'humanity's needs'—limitless fuel, for example—rather than 'our needs as individual, diverse and complex humans'. This is refreshing: worries about the separation between the top-down design of the future and those who must live with the designs are quite rare in science.
—New Scientist—
Synthetic Aesthetics is wise in not attempting a comprehensive survey of this fast changing and much contested industry, but by taking a collaborative approach that attempts to integrate design based questioning with scientific practice, it provides lots of juicy clues about where we could be headed.
—PostMatter—
Review
Just as post-war designers Ray and Charles Eames showed us how molded plywood techniques for building airplane wings could result in unexpected, and now timeless, pieces of furniture, artists and designers like Daisy Ginsberg are showing us how bacteria and other biological building blocks may give us entree to an entirely new species of experiences.
―John Maeda, Design Partner, Kleiner Perkins Caufield & Byers

As a condemned murderess stands before the court, her eyes meet those of the only man who believes in her innocence. But Hercule Poirot must prove it before it's too late.

【火车】 冒着火的车子，用来载生前做过恶事的亡灵前往地狱。
《观无量寿经》云：人以恶应堕恶道，命欲终时，地狱众火俱至，必有火车来迎。
《火车》于1993年荣获第6届山本周五郎奖
2008年荣获“这本推理小说了不起！”排行榜 “20年最佳”评选“专业人士部门”第1名、“读者投票部门”第2名
入选英国《卫报》推荐“亚洲10大推理悬疑小说”
《读卖新闻》称之为“日本20年来最了不起的推理悬疑小说”
《火车》具有浓郁的社会派色彩和典型的“宫部风情”，于无声处温婉从容地铺陈出一个曲折震撼的当代悲凉故事：
停职期间的警察本间受侄子的委托，帮忙寻找他突然杳无踪迹的未婚妻彰子。本间循着彰子的过往，逐渐发现她失踪的背后暗含无限隐情，她似乎一边在亡命奔逃，一边又时欲登上那辆凄凉的命运之车。
望着无边的黑暗，本间不由寒从心生：谁在追赶她？谁是“火车”上的魔鬼？她究竟在哪里？随着调查深入，悲凉骇人的真相缓缓打开……

Our genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on and off in many combinations to give the variety of cells from which our bodies are formed. But how do we identify the genes that make up our genome? How do we determine their function? And how do different genes form the regulatory networks that direct the processes of life? Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomes: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing. Covering the latest techniques that enable us to study the genome in ever-increasing detail, the book explores what the genome tells us about life at the level of the molecule, the cell, and the organism. Learning features throughout make this book the ideal teaching and learning tool: extensive end of chapter exercises and problems help the student to fully grasp the concepts being presented, while end of chapter weblems (web-based problems) and lab assignments give the student the opportunity to engage with the subject in a hands-on manner. The field of genomics is enabling us to analyze life in more detail than ever before; Introduction to Genomics is the perfect guide to this enthralling subject. Online Resource Centre The Online Resource Centre to accompany Introduction to Genomics features For lecturers: Figures from the book in electronic format For students: Answers to end-of-chapter exercises Guided tour of web sites in genomics Hints to end-of-chapter problems Rotating figures

A comprehensive account of genomic rearrangement, focusing on the mechanisms of inversion, translocation, gene and genome duplication and gene transfer and on the patterns that result from them in comparative maps. Includes analyses of genomic sequences in organelles, prokaryotes and eukaryotes as well as comparative maps of the nuclear genomes in higher plants and animals. The book showcases a variety of algorithmic and statistical approaches to rearrangement and map data.

祥子怀抱着母亲留给自己的婚纱，和Ｕ君来到了教堂。两人正欲举行婚礼之时，Ｕ君才发现婚戒落在了家中，急忙赶回去取。在教堂焦急等待的祥子，却等来了Ｕ君遭遇车祸的噩耗。她赶往医院，却被身份不明者劫持，惨遭凌辱。Ｕ君回到教堂，发现祥子已无踪影，只有两名自称是祥子未婚夫的男子。难道祥子脚踏三只船？

A comprehensive compendium of cutting-edge protocols for the generation of molecular diversity. Described in step-by-step detail to ensure experimental success, these protocols include readily reproducible methods for random mutagenesis of entire genes or segments of genes, for homologous and nonhomologus recombination, and for constructing in vivo libraries in bacteria and yeast. In addition to the various protocols for creating libraries, this volume also describes ways to analyze libraries, particularly those made by recombination. An accompanying volume, Directed Enzyme Evolution: Screening and Selection Methods (ISBN: 1-58829-286-X), is devoted entirely to selection and screening methods that can be applied to the directed evolution of enzymes. Copy for Both VolumesDirected Evolution Library Creation: Methods and Protocols and Directed Enzyme Evolution: Screening and Selection Methods constitute an extraordinary collection of all the key methods used today for directed evolution research. Described in step-by-step detail to ensure robust experimental results, these methods will enable both newcomers and more experienced investigators to design and implement directed evolution strategies for the engineering of novel proteins. The first volume describes methods for the creation of mutated DNA molecules, or DNA libraries, encoding variants of desired proteins. The second volume describes methods for screening DNA libraries to isolate mutant proteins that exhibit a specified function.

This volume and its companion, Volume 351, are specifically designed to meet the needs of graduate students and postdoctoral students as well as researchers, by providing all the up-to-date methods necessary to study genes in yeast. Procedures are included that enable newcomers to set up a yeast laboratory and to master basic manipulations. Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines. Specific topics addressed in this book include basic techniques, making mutants, genomics, and proteomics.

《彷徨之刃》是东野圭吾最具争议的小说，日文版销量已超过150万册
这不是事不关己的事，某一天你或许就会成为书中的主人公。那时，你手中的刀刃会指向何方？——东野圭吾
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长峰的女儿在看完烟火大会后彻夜未归，几天后尸体在荒川下游被人发现。正当长峰和警方都没有任何头绪时，他接到一个密报者的电话，知道了凶手的姓名和住址。
长峰潜入凶手家，看到了女儿遭受凌虐致死的录像，愤怒痛恨到几近崩溃。一直以来的守法公民决定执行“法外正义”，他乔装打扮，走上了复仇之路。

《理由》内容简介：地产泡沫破灭。雨夜，警局接到报案：美好新城2025号，小系一家四口惨遭灭门……，在宫部美雪不动声色的细密叙述中，这起灭门血案有如一块巨大的磁石，将人与人的疏离与冷漠、人与内心的矛盾与纠结、人与社会的失调与错位，织成一幅泡沫经济破灭后的浮世绘，如白描、如特写、如慢镜头一样苍凉地从天垂挂。

Robert Langdon, Harvard Professor of symbology, receives an urgent late-night call while in Paris: the curator of the Louvre has been murdered. Alongside the body is a series of baffling ciphers. Langdon and a gifted French cryptologist, Sophie Neveu, are stunned to find a trail that leads to the works of Da Vinci – and further. The curator, part of a secret society named the Priory of Sion, may have sacrificed his life to keep secret the location of a vastly important religious relic hidden for centuries. It appears that the clandestine Vatican-sanctioned Catholic sect Opus Dei has now made its move. Unless Landon and Neveu can decipher the labyrinthine code and quickly assemble the pieces of the puzzle, the Priory’s secret – and a stunning historical truth – will be lost forever.

Intended for the aspiring artist as well as the enthusiastic amateur, this invaluable guide to piano practice and performance covers every major aspect of pianistic technique. Drawing from more than forty years experience as a teacher and highly acclaimed performer—as well as from her studies with Rachmaninoff, Schnabel, and Cortot—Slenczynska clearly demonstrates such basics as the proper use of hand positions, fingering, pedaling, ornamentation, various fingering touches, and counting. She also gives detailed instructions on the art of program building, carefully analyzing the concert programs of Horowitz, Rubinstein, and Serkin and pointing out the strengths and weaknesses of their program construction. She includes repertoire lists for performance at various levels of ability, a complete chart of ornament interpretation, and authoritative advice on posture, sight-reading, rhythm, note-learning, and memorization. Her book is essential reading for all who enjoy in the piano-beginners, serious students, teachers, and listeners.