For three extraordinary seasons at Bayern Munich, Marti Perarnau was given total access around the German super club - to its players, its backroom staff, its board members and, above all, to its manager, Pep Guardiola. In the follow-up to his critically acclaimed account of Guardiola's first full season at Bayern, Pep Confidential, Perarnau now lifts the lid on the Catalan's whole tenure in Bavaria.
Pep Guardiola: The Evolution takes the reader on a journey through three action packed seasons as Bayern smashed domestic records yet struggled to emulate that dominance in Europe, analysing Guardiola's management style through key moments on and off the field. Perarnau reveals how Guardiola improved as a manager at Bayern despite failing to land the ultimate prize in European football, examines his decision to leave Germany to take up the challenge at Manchester City and how his managerial style will continue to evolve in the Premier League.
This is more than the story of three seasons with one of the biggest clubs in the game. It is a portrait and analysis of a manager and the footballing philosophies that have beguiled the world.

Methods in Yeast Genetics is a course that has been offered annually at Cold Spring Harbor Laboratory for the last thirty years. This is an updated edition of the course manual, which provides a set of teaching experiments, along with protocols and recipes for the standard techniques and reagents used in the study of yeast biology. Since the last edition of the manual was published (2000), revolutionary advances in genomics and proteomics technologies have had a significant impact on the field. This updated edition reflects these advances, and also includes new techniques involving vital staining, visualization of Green Fluorescent Protein, new drug resistance markers, high-copy suppression, Tandem Affinity Protein tag protein purification, gene disruption by double-fusion polymerase chain reaction, and many other recent developments.

Poirot sets himself a challenge before he retires - to solve 12 cases which correspond with the labours of his classical Greek namesake...In appearance Hercule Poirot hardly resembled an ancient Greek hero. Yet -- reasoned the detective -- like Hercules he had been responsible for ridding society of some of its most unpleasant monsters. So, in the period leading up to his retirement, Poirot made up his mind to accept just twelve more cases: his self-imposed 'Labours'. Each would go down in the annals of crime as a heroic feat of deduction.

Major New York Times bestseller
Winner of the National Academy of Sciences Best Book Award in 2012
Selected by the New York Times Book Review as one of the best books of 2011
A Globe and Mail Best Books of the Year 2011 Title
One of The Economist’s 2011 Books of the Year
One of The Wall Street Journal's Best Nonfiction Books of the Year 2011
In the international bestseller, Thinking, Fast and Slow, Daniel Kahneman, the renowned psychologist and winner of the Nobel Prize in Economics, takes us on a groundbreaking tour of the mind and explains the two systems that drive the way we think. System 1 is fast, intuitive, and emotional; System 2 is slower, more deliberative, and more logical. The impact of overconfidence on corporate strategies, the difficulties of predicting what will make us happy in the future, the profound effect of cognitive biases on everything from playing the stock market to planning our next vacation—each of these can be understood only by knowing how the two systems shape our judgments and decisions.
Engaging the reader in a lively conversation about how we think, Kahneman reveals where we can and cannot trust our intuitions and how we can tap into the benefits of slow thinking. He offers practical and enlightening insights into how choices are made in both our business and our personal lives—and how we can use different techniques to guard against the mental glitches that often get us into trouble. Winner of the National Academy of Sciences Best Book Award and the Los Angeles Times Book Prize and selected by The New York Times Book Review as one of the ten best books of 2011, Thinking, Fast and Slow is destined to be a classic.
One of the New York Times Book Review's Top 10 Books of 2011
Editorial Reviews
Amazon.com Review
Amazon Best Books of the Month, November 2011: Drawing on decades of research in psychology that resulted in a Nobel Prize in Economic Sciences, Daniel Kahneman takes readers on an exploration of what influences thought example by example, sometimes with unlikely word pairs like "vomit and banana." System 1 and System 2, the fast and slow types of thinking, become characters that illustrate the psychology behind things we think we understand but really don't, such as intuition. Kahneman's transparent and careful treatment of his subject has the potential to change how we think, not just about thinking, but about how we live our lives. Thinking, Fast and Slow gives deep--and sometimes frightening--insight about what goes on inside our heads: the psychological basis for reactions, judgments, recognition, choices, conclusions, and much more. --JoVon Sotak
Review
“A tour de force. . . Kahneman’s book is a must read for anyone interested in either human behavior or investing. He clearly shows that while we like to think of ourselves as rational in our decision making, the truth is we are subject to many biases. At least being aware of them will give you a better chance of avoiding them, or at least making fewer of them.”—Larry Swedroe, CBS News
“Daniel Kahneman demonstrates forcefully in his new book, Thinking, Fast and Slow, how easy it is for humans to swerve away from rationality.”—Christopher Shea, The Washington Post
“An outstanding book, distinguished by beauty and clarity of detail, precision of presentation and gentleness of manner. Its truths are open to all those whose System 2 is not completely defunct. I have hardly touched on its richness.”— Galen Strawson, The Guardian
“Brilliant . . . It is impossible to exaggerate the importance of Daniel Kahneman’s contribution to the understanding of the way we think and choose. He stands among the giants, a weaver of the threads of Charles Darwin, Adam Smith and Sigmund Freud. Arguably the most important psychologist in history, Kahneman has reshaped cognitive psychology, the analysis of rationality and reason, the understanding of risk and the study of happiness and well-being . . . A magisterial work, stunning in its ambition, infused with knowledge, laced with wisdom, informed by modesty and deeply humane. If you can read only one book this year, read this one.”— Janice Gross Stein, The Globe and Mail
“A sweeping, compelling tale of just how easily our brains are bamboozled, bringing in both his own research and that of numerous psychologists, economists, and other experts...Kahneman has a remarkable ability to take decades worth of research and distill from it what would be important and interesting for a lay audience...Thinking, Fast and Slow is an immensely important book. Many science books are uneven, with a useful or interesting chapter too often followed by a dull one. Not so here. With rare exceptions, the entire span of this weighty book is fascinating and applicable to day-to-day life. Everyone should read Thinking, Fast and Slow.” —Jesse Singal, Boston Globe
“We must be grateful to Kahneman for giving us in this book a joyful understanding of the practical side of our personalities.” —Freeman Dyson, The New York Review of Books
“Brilliant . . . It is impossible to exaggerate the importance of Daniel Kahneman’s contribution to the understanding of the way we think and choose. He stands among the giants, a weaver of the threads of Charles Darwin, Adam Smith and Sigmund Freud. Arguably the most important psychologist in history, Kahneman has reshaped cognitive psychology, the analysis of rationality and reason, the understanding of risk and the study of happiness and well-being . . . A magisterial work, stunning in its ambition, infused with knowledge, laced with wisdom, informed by modesty and deeply humane. If you can read only one book this year, read this one.” — Janice Gross Stein, The Globe and Mail
“It is an astonishingly rich book: lucid, profound, full of intellectual surprises and self-help value. It is consistently entertaining and frequently touching, especially when Kahneman is recounting his collaboration with Tversky . . . So impressive is its vision of flawed human reason that the New York Times columnist David Brooks recently declared that Kahneman and Tversky’s work ‘will be remembered hundreds of years from now,’ and that it is ‘a crucial pivot point in the way we see ourselves.’ They are, Brooks said, ‘like the Lewis and Clark of the mind’ . . . By the time I got to the end of Thinking, Fast and Slow, my skeptical frown had long since given way to a grin of intellectual satisfaction. Appraising the book by the peak-end rule, I overconfidently urge everyone to buy and read it. But for those who are merely interested in Kahenman’s takeaway on the Malcolm Gladwell question it is this: If you've had 10,000 hours of training in a predictable, rapid-feedback environment—chess, firefighting, anesthesiology—then blink. In all other cases, think.”—The New York Times Book Review
“Ask around and you hear pretty much the same thing. 'Kahneman is the most influential psychologist since Sigmund Freud,' says Christopher Chabris, a professor of psychology at Union College, in New York. 'No one else has had such a broad impact on so many fields' . . . It now seems inevitable that Kahneman, who made his reputation by ignoring or defying conventional wisdom, is about to be anointed the intellectual guru of our economically irrational times.”— Evan R. Goldstein, The Chronicle of Higher Education
“There have been many good books on human rationality and irrationality, but only one masterpiece. That masterpiece is Daniel Kahneman’s Thinking, Fast and Slow . . . This is one of the greatest and most engaging collections of insights into the human mind I have read.”—William Easterly, Financial Times
“[Thinking, Fast and Slow] is wonderful, of course. To anyone with the slightest interest in the workings of his own mind, it is so rich and fascinating that any summary would seem absurd.”— Michael Lewis, Vanity Fair
“Absorbingly articulate and infinitely intelligent . . . What's most enjoyable and compelling about Thinking, Fast and Slow is that it's so utterly, refreshingly anti-Gladwellian. There is nothing pop about Kahneman's psychology, no formulaic story arc, no beating you over the head with an artificial, buzzword-encrusted Big Idea. It's just the wisdom that comes from five decades of honest, rigorous scientific work, delivered humbly yet brilliantly, in a way that will forever change the way you think about thinking.”—Maria Popova, The Atlantic
“I will never think about thinking quite the same. [Thinking, Fast and Slow] is a monumental achievement.”—Roger Lowenstein, Bloomberg/Businessweek
“Profound . . . As Copernicus removed the Earth from the centre of the universe and Darwin knocked humans off their biological perch, Mr. Kahneman has shown that we are not the paragons of reason we assume ourselves to be.” —The Economist
“[Kahneman’s] disarmingly simple experiments have profoundly changed the way that we think about thinking . . . We like to see ourselves as a Promethean species, uniquely endowed with the gift of reason. But Mr. Kahneman’s simple experiments reveal a very different mind, stuffed full of habits that, in most situations, lead us astray.” —Jonah Lehrer, The Wall Street Journal
“[A] tour de force of psychological insight, research explication and compelling narrative that brings together in one volume the high points of Mr. Kahneman's notable contributions, over five decades, to the study of human judgment, decision-making and choice . . . Thanks to the elegance and force of his ideas, and the robustness of the evidence he offers for them, he has helped us to a new understanding of our divided minds—and our whole selves.” —Christoper F. Chabris, The Wall Street Journal
“The ramifications of Kahenman’s work are wide, extending into education, business, marketing, politics . . . and even happiness research. Call his field “psychonomics,” the hidden reasoning behind our choices. Thinking, Fast and Slow is essential reading for anyone with a mind.” —Kyle Smith, The New York Post
“A major intellectual event . . . The work of Kahneman and Tversky was a crucial pivot point in the way we see ourselves.” —David Brooks, The New York Times
“Kahneman provides a detailed, yet accessible, description of the psychological mechanisms involved in making decisions.” —Jacek Debiec, Nature
“With Kahneman’s expert help, readers may understand this mix of psychology and economics better than most accountants, therapists, or elected representatives. VERDICT A stellar accomplishment, a book for everyone who likes to think and wants to do it better.” —Library Journal
“The mind is a hilariously muddled compromise between incompatible modes of thought in this fascinating treatise by a giant in the field of decision research. Nobel-winning psychologist Kahneman (Attention and Effort) posits a brain governed by two clashing decision-making processes. The largely unconscious System 1, he contends, makes intuitive snap judgments based on emotion, memory, and hard-wired rules of thumb; the painfully conscious System 2 laboriously checks the facts and does the math, but is so "lazy" and distractible that it usually defers to System 1. Kahneman uses this scheme to frame a scintillating discussion of his findings in cognitive psychology and behavioral economics, and of the ingenious experiments that tease out the irrational, self-contradictory logics that underlie our choices. We learn why we mistake statistical noise for cohere...

This book provides a concise, approachable description of how modern NMR experiments work, aimed principally at those who use, or might use, an NMR spectrometer and are curious about why the spectra look the way they do. It provides, in an accessible and relatively informal fashion, the conceptual and theoretical tools needed to understand the inner workings of some of the most important multi-pulse, multi-nuclear, multi-dimensional techniques that chemists and biochemists use to probe the structures and dynamics of molecules in liquids.
Part A (chapters 1-6) starts with the vector model, and proceeds to the more powerful product operator formalism. Part B (chapters 7-10) shows how straightforward quantum mechanics can be used to understand NMR and product operators at a more fundamental level.

A dark offering from the Queen of Crime. This represents the world-famous author's most successful foray into the dark world of murder and black magic. To understand the strange goings on at The Pale Horse Inn, Mark Easterbrook knew he had to begin at the beginning. But where exactly was the beginning?Was it the savage blow to the back of Father Gorman's head? Or was it when the priest's assailant searched him so roughly he tore the clergyman's cassock? Or could it have been the priest's visit, just minutes before, to a woman on her death bed?Or was there a deeper significance to the violent squabble which Mark Easterbrook had himself witnessed earlier?Wherever the beginning lies, Mark and his sidekick, Ginger Corrigan, may soon have cause to wish they'd never found it... --This text refers to an out of print or unavailable edition of this title.

Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful technique in structural biology for obtaining high resolution 3-D structures of proteins, second only, and complementary to X-ray crystallography. Molecules are studied in solution, where conditions are closer to what is found in the cell. It is the primary technique used to obtain information on intrinsically disordered (unfolded) proteins, since these proteins will not crystallize easily. The aim of this book is to provide the newcomer to NMR techniques with practical guidance on how to choose the right experiment, how to carry out the experiment, and how to analyse the resulting spectra. Those who are familiar with the chemical applications of NMR will also find it helpful in describing the special requirements of proteins.

Reviews of the Second Edition
"In this book, Andy Baxevanis and Francis Ouellette . . . have undertaken the difficult task of organizing the knowledge in this field in a logical progression and presenting it in a digestible form. And they have done an excellent job. This fine text will make a major impact on biological research and, in turn, on progress in biomedicine. We are all in their debt."--Eric Lander, from the Foreword to the Second Edition
"The editors and the chapter authors of this book are to be applauded for providing biologists with lucid and comprehensive descriptions of essential topics in bioinformatics. This book is easy to read, highly informative, and certainly timely. It is most highly recommended for students and for established investigators alike, for anyone who needs to know how to access and use the information derived in and from genomic sequencing projects."--Trends in Genetics
"It is an excellent general bioinformatics text and reference, perhaps even the best currently available . . . Congratulations to the authors, editors, and publisher for producing a weighty, authoritative, readable, and attractive book."--Briefings in Bioinformatics
"This book, written by the top scientists in the field of bioinformatics, is the perfect choice for every molecular biology laboratory."--The Quarterly Review of Biology
This fully revised version of a world-renowned bestseller provides readers with a practical guide covering the full scope of key concepts in bioinformatics, from databases to predictive and comparative algorithms. Using relevant biological examples, the book provides background on and strategies for using many of the most powerful and commonly used computational approaches for biological discovery. This Third Edition reinforces key concepts that have stood the test of time while making the reader aware of new and important developments in this fast-moving field. With a new full-color and enlarged page design, Bioinformatics, Third Edition offers the most readable, up-to-date, and thorough introduction to the field for biologists.
This new edition features:
* New chapters on genomic databases, predictive methods using RNA sequences, sequence polymorphisms, protein structure prediction, intermolecular interactions, and proteomic approaches for protein identification
* Detailed worked examples illustrating the strategic use of the concepts presented in each chapter, along with a collection of expanded,more rigorous problem sets suitable for classroom use
* Special topic boxes and appendices highlighting experimental strategies and advanced concepts
* Annotated reference lists, comprehensive lists of relevant Web resources, and an extensive glossary of commonly used terms in bioinformatics, genomics, and proteomics
Bioinformatics, Third Edition is essential reading for researchers, instructors, and students of all levels in molecular biology and bioinformatics, as well as for investigators involved in genomics, clinical research, proteomics, and computational biology.

A Nobel Prize-winning biologist tells the riveting story of his race to discover the inner workings of biology's most important molecule
"Ramakrishnan's writing is so honest, lucid and engaging that I could not put this book down until I had read to the very end."
--Siddhartha Mukherjee, author of The Emperor of All Maladies and The Gene
Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome--an enormous molecular machine made up of a million atoms--that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

A simple yet comprehensive guide to the types of psychologies and therapies available from Eastern and Western sources. Each chapter includes a specific exercise designed to help the reader understand the nature and practice of the specific therapies. Wilber presents an easy-to-use map of human consciousness against which the various therapies are introduced and explained. This edition includes a new preface.

The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series,
and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.

Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The text avoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. "An Introduction to Systems Biology: Design Principles of Biological Circuits" builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.

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Hercule Poirot’s relaxing holiday on the Cornish coast takes an unexpected turn when he meets young and pretty Nick Buckley. For it seems to Poirot that too many accidents have been happening to Nick and he, with the help of Captain Hastings, is determined to prevent another accident becoming a tragedy.
But even hiding Nick away in a nursing home does not prevent another attempt on Nick’s life and Poirot has to resort to subterfuge and cunning to solve this tricky case.

Yeast has been a preeminent experimental organism of genetic research for more than 50 years. Progress in the field has provided the conceptual framework that has driven experiments in many areas of biology. Landmark Papers in Yeast Biology consists of essays by prominent scientists on the context and significance of 71 carefully selected research papers, which are reprinted on the accompanying CD. The papers include early, hard-to-find classics as well as more recent advances in areas such as signal transduction, membrane trafficking, protein turnover, and genomics. This collection has unique value for all scholars of yeast and could provide the foundation for a literature-based course on molecular cell biology. As Jasper Rine notes in his eloquent introduction, the editors and contributors share the belief that deep study of the agreed-on classics is the best training for learning how to recognize those contemporary papers worthy of our personal time...

Generally considered to be F. Scott Fitzgerald's finest novel, The Great Gatsby is a consummate summary of the 'roaring twenties' and a devastating expose of the 'Jazz Age'. Through the narration of Nick Carraway, the reader is taken into the superficially glittering world of the mansions which lined the Long Island shore of the American seaboard in the 1920s, to encounter Nick's cousin Daisy, Jay Gatsby and the dark mystery which surrounds him. The Great Gatsby is an undisputed classic of American literature from the period following the First World War and is one of the great novels of the twentieth century.

Stephen Paddock and a highly skilled panel of experts lead the researcher using confocal techniques from the bench top, through the imaging process, to the journal page. They concisely describe all the key stages of confocal imaging-from tissue sampling methods, through the staining process, to the manipulation, presentation, and publication of the realized image. Written in a user-friendly, nontechnical style, the methods specifically cover most of the commonly used model organisms: worms, sea urchins, flies, plants, yeast, frogs, and zebrafish. The powerful hands-on methods collected here will help even the novice to produce first-class cover-quality confocal images.